Search results for " Antifungal therapy"

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Procalcitonin as a marker of Candida species detection by blood culture and polymerase chain reaction in septic patients

2014

Background: The aim of our study is to test procalcitonin (PCT) as surrogate marker of identification of Candida spp. by blood culture (BC) and real-time-polymerase chain reaction (PCR), whether alone or in association with bacteria, in septic patients.Methods: We performed a single-centre retrospective study. We reviewed the clinical charts of patients with a diagnosis of severe sepsis or septic shock treated at our general intensive care unit from March 2009 to March 2013. We analysed all diagnostic episodes consisting of BC, real-time PCR assay and dosage of PCT. We registered age, sex, white blood count, sequential organ failure assessment score and type of admission between medical or …

Fungal infectionMalePathologyProtein PrecursorSettore MED/41 - AnestesiologiaProcalcitoninlaw.inventionRetrospective StudielawBlood cultureAntifungal therapyPolymerase chain reactionCandidaAged 80 and overmedicine.diagnostic_testbiologyMiddle AgedShock SepticPolymerase chain reactionBlood stream infectionReal-time polymerase chain reactionFemaleProcalcitoninProcalcitonin Sepsis Candida species Blood stream infection Fungal infection Polymerase chain reaction Antifungal therapyhormones hormone substitutes and hormone antagonistsResearch ArticleHumanCalcitoninmedicine.medical_specialtySepsiCalcitonin Gene-Related PeptideReal-Time Polymerase Chain ReactionMicrobiologySepsisSepsisparasitic diseasesCandida speciesmedicineHumansProtein PrecursorsMED/41 - ANESTESIOLOGIAAntifungal therapy; Blood stream infection; Candida species; Fungal infection; Polymerase chain reaction; Procalcitonin; SepsisRetrospective StudiesAgedbusiness.industrySurrogate endpointBiomarkerbacterial infections and mycosesmedicine.diseasebiology.organism_classificationAnesthesiology and Pain MedicineCalcitoninCandida speciebusinessBiomarkersBacteriaBMC Anesthesiology
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A prospective, randomized study of empirical antifungal therapy for the treatment of chemotherapy-induced febrile neutropenia in children

2012

Given that the rationale for empirical antifungal therapy in neutropenic children is limited and based on adult patient data, we performed a prospective, randomized, controlled trial that evaluated 110 neutropenic children with persistent fever. Those at high risk for invasive fungal infections (IFI) received caspofungin (Arm C) or liposomal amphotericinB (Arm B); those with a lower risk were randomized to receive Arm B, C, or no antifungal treatment (Arm A). Complete response to empirical antifungal therapy was achieved in 90/104 patients (86·5%): 48/56 at high risk (85·7%) [88·0% in Arm B; 83·9% in Arm C (P = 0·72)], and 42/48 at low risk (87·5%) [87·5% in control Arm A, 80·0% Arm B, 94·1…

Malemedicine.medical_specialtyAntifungal AgentsNeutropeniaAntineoplastic AgentsOpportunistic InfectionsLower riskFever of Unknown Originlaw.inventionEchinocandinsLipopeptideschemistry.chemical_compoundRandomized controlled trialCaspofunginlawAmphotericin BInternal medicinemedicineHumansProspective StudiesChildProspective cohort studyempirical antifungal therapy children cancerbusiness.industryPatient SelectionInfantCancerHematologyLength of Staymedicine.diseaseConfidence intervalSurgeryHospitalizationTreatment OutcomeMycoseschemistryChild PreschoolFemaleCaspofunginbusinessEmpiric therapyFebrile neutropeniaBritish Journal of Haematology
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